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KMID : 1188320100040020266
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Gut and Liver
2010 Volume.4 No. 2 p.266 ~ p.269
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Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy
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Kim Yong-Gil
Eun Jong-Ryul
Kim Tae-Nyeun
Lee Heon-Ju
Kim Jae-Woon
Chang Jay-Chun
Yun Sung-Soo
Choi Joon-Hyuk
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Abstract
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Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT.
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KEYWORD
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Hepatocellular carcinoma, Portal vein tumor thrombosis, Chemotherapy, 5-fluorouracil, Complete remission
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